Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease
نویسندگان
چکیده
منابع مشابه
Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease.
This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies began by confirming the hypothesis that chronic dietary poisoning by aristolochic acid was responsible for endemic (Balkan) nephropathy. A unique TP53 mutational signature in urothelial tumors and the presence of ...
متن کاملEndemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
متن کاملAristolochic Acid as a Risk Factor for Balkan Endemic Nephropathy
Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia Department of Biochemistry, Charles University, Prague, The Czech Republic Ecole Nationale Supérieure Agronomique de Toulouse, Laborat...
متن کاملAristolochic acid nephropathy complicating a patient with focal segmental glomerulosclerosis.
A 75-year-old Chinese male was admitted to hospital with a 1 week history of ankle oedema, facial puffiness and frothy urine. He had no sore throat, smoky urine, rash, joint pain, fever, night sweat or weight loss. He did not experience shortness of breath. Five weeks before, he was admitted for insidious onset of rightsided weakness with a 1 year history of chronic neck pain after an accidenta...
متن کاملMechanism of chronic aristolochic acid nephropathy: role of Smad3.
Aristolochic acid nephropathy (AAN) has become a worldwide disease and is the most severe complication related to the use of traditional Chinese medicine. However, the pathogenic mechanisms of AAN remain unclear and therapies are limited. The present study tested the hypothesis that transforming growth factor (TGF)-beta/Smad3 may be a key pathway leading to chronic AAN. This was examined in viv...
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ژورنال
عنوان ژورنال: Environmental and Molecular Mutagenesis
سال: 2012
ISSN: 0893-6692
DOI: 10.1002/em.21756